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05 June 2016 : Animal Research  

Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury

Umit OzcelikABCDEF, Yahya EkiciA, Huseyin Yuce BircanCE, Cem AydoganDE, Suna TurkogluBCD, Ozlem OzenBCD, Gokhan MorayD, Mehmet HaberalD

DOI: 10.12659/MSM.895395

Med Sci Monit 2016; 22:1903-1909

Abstract

BACKGROUND: To investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model.

MATERIAL AND METHODS: Thirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury. Tissue hydroxyproline levels were measured and histopathologic changes were examined.

RESULTS: Hydroxyproline levels were significantly higher in the platelet-rich plasma group than in the control group (P=.03). Histopathologically, there was significantly less inflammatory cell infiltration (P=.005) and there were no statistically significant differences between groups in fibroblast development, collagen production, vessel proliferations, or epithelization.

CONCLUSIONS: Platelet-rich plasma seems to partially improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet-rich plasma can be used in humans, although further studies should be performed with this type of treatment.

Keywords: Burns - therapy, Hydroxyproline - metabolism, platelet-rich plasma, Random Allocation, Rats, Wistar, Wound Healing

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750