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Medical Science Monitor Basic Research


eISSN: 1643-3750

Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury

Umit Ozcelik, Yahya Ekici, Huseyin Yuce Bircan, Cem Aydogan, Suna Turkoglu, Ozlem Ozen, Gokhan Moray, Mehmet Haberal

Department of General Surgery, Baskent University School of Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey

Med Sci Monit 2016; 22:1903-1909

DOI: 10.12659/MSM.895395

Available online:

Published: 2016-06-05


BACKGROUND: To investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model.
MATERIAL AND METHODS: Thirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury. Tissue hydroxyproline levels were measured and histopathologic changes were examined.
RESULTS: Hydroxyproline levels were significantly higher in the platelet-rich plasma group than in the control group (P=.03). Histopathologically, there was significantly less inflammatory cell infiltration (P=.005) and there were no statistically significant differences between groups in fibroblast development, collagen production, vessel proliferations, or epithelization.
CONCLUSIONS: Platelet-rich plasma seems to partially improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet-rich plasma can be used in humans, although further studies should be performed with this type of treatment.

Keywords: Burns - therapy, Animals, Disease Models, Animal, Hydroxyproline - metabolism, platelet-rich plasma, Random Allocation, Rats, Rats, Wistar, Wound Healing