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13 March 2016 : Meta-Analysis  

Correlations Between Abnormal Glucose Metabolism and Bone Mineral Density or Bone Metabolism

Yang QuCD, Ming-Yang KangC, Rong-Peng DongE, Jian-Wu ZhaoAB

DOI: 10.12659/MSM.895387

Med Sci Monit 2016; 22:824-832

Abstract

BACKGROUND: The aim of this meta-analysis was to explore the correlations of abnormal glucose metabolism (AGM) with bone mineral density (BMD) and bone metabolism.

MATERIAL AND METHODS: Relevant studies were identified using computerized and manual search strategies. The included studies were in strict accordance with inclusion and exclusion criteria. Statistical analyses were conducted with the Comprehensive Meta-analysis 2.0 (Biostat Inc., Englewood, NJ, USA).

RESULTS: Our present meta-analysis initially searched 844 studies, and 7 studies were eventually incorporated in the present meta-analysis. These 7 cohort studies included 1123 subjects altogether (560 patients with AGM and 563 healthy controls). The results showed that bone mass index (BMI), insulin, and insulin resistance (IR) of patients with AGM were significantly higher than that of the population with normal glucose metabolism (BMI: SMD=1.658, 95% CI=0.663~2.654, P=0.001; insulin: SMD=0.544, 95% CI=0.030~1.058, P=0.038; IR: SMD=8.767, 95% CI=4.178~13.356, P<0.001). However, the results also indicated there was no obvious difference in osteocalcin (OC) and BMD in patients with AGM and the population with normal glucose metabolism (OC: SMD=0.293, 95% CI=–0.023~0.609, P=0.069; BMD: SMD=0.805, 95% CI=–0. 212~1.821, P=0.121).

CONCLUSIONS: Our meta-analysis results suggest that AGM might lead to increased BMI, insulin, and IR, while it has no significant correlation with BMD or bone metabolism.

Keywords: Body Mass Index, Bone Density, Bone and Bones - metabolism, Case-Control Studies, Child, Glucose - metabolism, Insulin - metabolism, Insulin Resistance, Osteocalcin - metabolism, Publication Bias

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750