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25 April 2016 : Clinical Research

Determination of Serum Ceruloplasmin Concentration in Patients with Primary Open Angle Glaucoma with Cataract and Patients with Cataract Only: A Pilot Study

Monika Sarnat-KucharczykABCDEF, Wojciech RokickiABCDE, Jolanta Zalejska-FiolkaABDF, Dorota Pojda-WilczekABCEF, Ewa Mrukwa-KominekABCEG

DOI: 10.12659/MSM.895352

Med Sci Monit 2016; 22:1384-1388

Abstract

BACKGROUND: The aim of this article was to describe the role of ceruloplasmin and to report preliminary results of ceruloplasmin concentrations in patients with primary open-angle glaucoma (POAG) with cataract and in patients with only cataract. Glaucoma, a neurodegenerative disease, is a heterogeneous group of conditions characterized by loss of retinal ganglion cells (RGC), their axons, progressive optic nerve damage, and visual field deterioration.

MATERIAL AND METHODS: The POAG group included 30 patients and the cataract group included 25 patients.

RESULTS: Ceruloplasmin plays an essential role in iron metabolism and inactivating free radicals. In the presented pilot study, serum ceruloplasmin level was lower in the POAG group in comparison to the group with only cataract.

CONCLUSIONS: In treating persistent inflammation in the course of glaucoma, antiglaucoma drugs may increase the permeability of the blood-ocular barrier, which may be connected with the lower concentration of serum ceruloplasmin in the glaucoma patients group.

Keywords: Cataract - complications, Ceruloplasmin - metabolism, Glaucoma, Open-Angle - complications, Pilot Projects

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750