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eISSN: 1643-3750

Relationship Between Interleukin-10 Gene C-819T Polymorphism and Gastric Cancer Risk: Insights From a Meta-Analysis

Xigang Cui, Qingxian Huang, Xianglin Li, Fang Liu, Dan Wang, Dong Yan, Bin Wang, Chunhua Yang, Jia Mi, Geng Tian

Department of Gastric and Intestine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China (mainland)

Med Sci Monit 2016; 22:2839-2845

DOI: 10.12659/MSM.895333

Available online:

Published: 2016-08-12


#895333

BACKGROUND: As a pleiotropic cytokine, interleukin-10 (IL-10) plays a regulatory role in carcinogenesis and tumor growth. The aim of this meta-analysis was to assess the susceptibility of the IL-10 gene C-819T polymorphism to gastric cancer.
MATERIAL AND METHODS: Study identification and data extraction were independently completed by 2 authors. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated and summarized.
RESULTS: In total, 11 articles including 1960 gastric cancer patients and 3705 controls were qualified. Overall analyses revealed a 13% reduced risk of gastric cancer conferred by the –819T allele relative to the –819C allele (OR=0.87; 95% CI: 0.77–0.97; P=0.016), without heterogeneity (I2=35.1%). In subgroup analyses, a significant difference was identified in East Asian populations (OR=0.85; 95% CI: 0.73–0.98; P=0.029, I2=43.6%), for gastric adenocarcinoma (OR=0.80; 95% CI: 0.66–0.96; P=0.017, I2=0.0%), and in population-based studies (OR=0.81; 95% CI: 0.70–0.93; P=0.003, I2=0.0%). The visual funnel plots and Egger’s tests suggested no evidence of publication bias.
CONCLUSIONS: Extending previous findings, we demonstrate a protective role of the IL-10 gene –819T allele in susceptibility to gastric cancer, and this role was more evident for gastric adenocarcinoma.

Keywords: Gene Frequency, Alleles, Genetic Predisposition to Disease, Haplotypes, Interleukin-10 - metabolism, Odds Ratio, Polymorphism, Single Nucleotide, Risk Factors, Stomach Neoplasms - metabolism



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