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Association Between Polymorphism rs678653 in Human Cyclin D1 Gene (CCND1) and Susceptibility to Cancer: A Meta-Analysis

Xichao Dai, Xizhi Zhang, Buhai Wang, Chaomin Wang, Jingting Jiang, Changping Wu

Department of Tumor Biological Treatment, The third Affiliated Hospital, Soochow University, Suzhou, Jiangsu, China (mainland)

Med Sci Monit 2016; 22:863-874

DOI: 10.12659/MSM.895237

Available online:

Published: 2016-03-16

BACKGROUND: To assess the association between polymorphism rs678653 in human Cyclin D1 gene (CCND1) and the risk of cancer.
MATERIAL AND METHODS: Multiple biomedical databases were systematically searched. Pooled odds ratios (OR) and 95% confidence intervals (95% CIs) were calculated in the appropriate model.
RESULTS: In total, 17 case-control studies from 14 articles were included. When combing all available data, no significant association of rs678653 with cancer risk was observed under different genetic models. Stratification by ethnicity also indicated that rs678653 was not correlated with cancer risk in Taiwanese or Indian populations. When stratified by cancer type, no significant association was found between polymorphism rs678653 and digestive tract cancer, head and neck cancer, and gynecological cancer risk.
CONCLUSIONS: Our comprehensive meta-analysis suggests that the polymorphism rs678653 in CCND1 has no association with cancer risk in different population and disease contexts, indicating that CCND1 rs678653 does not serve a significant biological function in predicting cancer risk.

Keywords: Cyclin D1 - genetics, Genes, Recessive, Genetic Association Studies, Genetic Predisposition to Disease, India, Models, Genetic, Neoplasms - genetics, Polymorphism, Single Nucleotide - genetics, Taiwan