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01 December 2015 : Meta-Analysis

Association Between COX-2 Polymorphisms and Lung Cancer Risk

Weiwei WangABDG, Xinyun FanBD, Yong ZhangDE, Yi YangCE, Siyuan YangBE, Gaofeng LiEFG

DOI: 10.12659/MSM.894839

Med Sci Monit 2015; 21:3740-3747

Abstract

BACKGROUND: Multiple relevant risk factors for lung cancer have been reported in different populations, but results of previous studies were not consistent. Therefore, a meta-analysis is necessary to summarize these outcomes and reach a relatively comprehensive conclusion.

MATERIAL AND METHODS: STATA 12.0 software was used for all statistical of the relationship between COX-2 polymorphisms and lung cancer risk. Inter-study heterogeneity was examined with the Q statistic (significance level at P<0.1). The publication bias among studies in the meta-analysis was analyzed with Begg’s funnel plot and Egger’s test. Hardy-Weinberg equilibrium was tested in all controls of the studies.

RESULTS: COX-2 rs20417 polymorphism had a significant association with reduced risk of lung cancer under homozygous and recessive models, and similar results were observed in white and population-based subgroups under 2 and 3 contrasts, respectively. Additionally, rs2066826 polymorphism manifested a strong correlation with increased risk of lung cancer under 5 genetic models.

CONCLUSIONS: In COX-2 gene, rs20417 may have a certain relationship with reduced risk of lung cancer, while rs2066826 may increase the risk of lung cancer.

Keywords: Cyclooxygenase 2 - genetics, Case-Control Studies, Genetic Association Studies, Genetic Predisposition to Disease, Lung Neoplasms - genetics, Polymorphism, Single Nucleotide, Software

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750