Association Between COX-2 Polymorphisms and Lung Cancer Risk
Weiwei Wang, Xinyun Fan, Yong Zhang, Yi Yang, Siyuan Yang, Gaofeng Li
Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Provincial Tumor Hospital, Kunming, Yunnan, China (mainland)
Med Sci Monit 2015; 21:3740-3747
DOI: 10.12659/MSM.894839
Available online: 2015-12-01
Published: 2015-12-01
BACKGROUND:
Multiple relevant risk factors for lung cancer have been reported in different populations, but results of previous studies were not consistent. Therefore, a meta-analysis is necessary to summarize these outcomes and reach a relatively comprehensive conclusion.
MATERIAL AND METHODS:
STATA 12.0 software was used for all statistical of the relationship between COX-2 polymorphisms and lung cancer risk. Inter-study heterogeneity was examined with the Q statistic (significance level at P<0.1). The publication bias among studies in the meta-analysis was analyzed with Begg’s funnel plot and Egger’s test. Hardy-Weinberg equilibrium was tested in all controls of the studies.
RESULTS:
COX-2 rs20417 polymorphism had a significant association with reduced risk of lung cancer under homozygous and recessive models, and similar results were observed in white and population-based subgroups under 2 and 3 contrasts, respectively. Additionally, rs2066826 polymorphism manifested a strong correlation with increased risk of lung cancer under 5 genetic models.
CONCLUSIONS:
In COX-2 gene, rs20417 may have a certain relationship with reduced risk of lung cancer, while rs2066826 may increase the risk of lung cancer.
Keywords: Cyclooxygenase 2 - genetics, Case-Control Studies, Genetic Association Studies, Genetic Predisposition to Disease, Lung Neoplasms - genetics, Polymorphism, Single Nucleotide, Software
