Meta-Analysis on the Correlation Between APOM rs805296 Polymorphism and Risk of Coronary Artery Disease
HongYan Sun, Dong Shen, ChunHong Zhang, DangSheng Huang, YuMei Wang, LiWei Zhang
Department of Cardiology, The First Affiliated Hospital of PLA General Hospital, Beijing, China (mainland)
Med Sci Monit 2016; 22:8-13
Available online: 2016-01-02
The present meta-analysis aimed to summarize the inconsistent findings on the association of apolipoprotein M gene (ApoM) rs805296 polymorphism with the risk of coronary artery disease (CAD), and to obtain a more authentic result about this topic.
MATERIAL AND METHODS: A total of 7 available articles were identified through electronic databases – PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) – and their useful data were carefully extracted. The relationship between ApoM rs805296 polymorphism and CAD risk was assessed by odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs), which were calculated using the fixed- or random-effects model, according to the degree of heterogeneity. Hardy-Weinberg equilibrium test, sensitivity test, and publication bias examination were also performed in this meta-analysis.
RESULTS: According to the pooled results, ApoM rs805296 polymorphism conferred an increased risk of CAD under all the genetic contrasts: CC versus TT, CC + TC versus TT, CC versus TT+TC, C versus T, and TC versus TT (OR=2.13, 95% CI=1.16–3.91; OR=1.80, 95% CI=1.50–2.17; OR=1.91, 95% CI=1.04–3.51; OR=1.72, 95% CI=1.45–2.04; OR=1.78, 95% CI=1.47–2.15).
CONCLUSIONS: ApoM rs805296 polymorphism may be a risk factor for developing CAD.
Keywords: Case-Control Studies, Apolipoproteins - genetics, China, Coronary Artery Disease - genetics, Gene Frequency, Genetic Predisposition to Disease, Genotype, Lipocalins - genetics, Odds Ratio, Polymorphism, Single Nucleotide, Promoter Regions, Genetic - genetics, Risk Factors, Triglycerides - blood