Epidemiological Investigation and Risk Factors for Cervical Lesions: Cervical Cancer Screening Among Women in Rural Areas of Henan Province China
Qingwei Zhang, Wenyan Xie, Feng Wang, Rong Hong Li, Lina Cui, Huifen Wang, Xiuhong Fu, Jiayu Song
Department of Obstetrics and Gynecology, Luohe Medical College First Affiliated Hospital, Luohe, Henan, China (mainland)
Med Sci Monit 2016; 22:1858-1865
This cross-sectional study aimed to investigate the prevalence of cervical lesions and evaluate risk factors for cervical intraepithelial neoplasia (CIN) among women taking part in cervical cancer screening in rural areas of Henan province, China.
MATERIAL AND METHODS: Cervical cancer screening using the ThinPrep cytologic test (TCT) and gynecologic exam was conducted on 1315 women age 20–68 years in rural areas of Henan province, China. Colposcopy and biopsies were carried out for histopathologic diagnosis when indicated. Univariate and multivariate logistic regressions were performed to evaluate risk factors associated with cervical lesions.
RESULTS: Among 1315 women screened, CIN prevalence detected by histopathology was 1.22% (0.38% of CIN 1, 0.76% of CIN 2, and 0.08% of CIN 3). Cervical cancer prevalence was 2.66%. Multivariate analysis confirmed risk factors for cervical lesions included older age (the 21–40 age group vs. the 41–66 age group, OR=0.13, 95% CI: 0.03~0.57), postmenopause (OR=0.11, 95% CI: 0.03~0.45), cervical inflammation (OR=0.06, 95% CI: 0.01~0.31), and smoking (OR=6.78, 95% CI: 1.20~38.23).
CONCLUSIONS: Older age (41–66 years), presence of HPV infection, postmenopause, cervical inflammation, and smoking are strong risk factors for cervical lesions among women in rural areas of Henan province, China. Particular efforts should be made to provide cervical cancer screening for these women.
Keywords: Adult, Biopsy, Cervical Intraepithelial Neoplasia - virology, China - epidemiology, Colposcopy, Cross-Sectional Studies, Early Detection of Cancer, Mass Screening - methods, Papillomavirus Infections - epidemiology, Prevalence, Risk Factors, Rural Population - statistics & numerical data, Squamous Intraepithelial Lesions of the Cervix - virology, Uterine Cervical Neoplasms - virology