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13 May 2015 : Clinical Research

Serum Galectin-3 Levels in Children with Chronic Hepatitis B Infection and Inactive Hepatitis B Carriers

Ünal UlucaACD, Velat ŞenBDF, Aydın EceCE, İlhan TanBD, Duran KarabelEF, Fesih AktarAE, Müsemma KarabelDE, Hasan BalıkEF, Ali GüneşAF

DOI: 10.12659/MSM.894035

Med Sci Monit 2015; 21:1376-1380

Abstract

BACKGROUND: Chronic hepatitis B virus (HBV) infection is common worldwide. Follow-up of patients by the use of non-invasive techniques may be valuable in clinical practice. The aim of this study was to investigate serum galectin-3 (GAL-3) levels for monitoring disease status in children with chronic HBV infection.

MATERIAL AND METHODS: Thirty-two patients with chronic hepatitis B (CHB), 30 inactive HBV carrier patients, and 30 matched healthy controls were enrolled in the study. We performed basic laboratory tests: serum glucose, albumin, alanine aminotransferase (ALT), aspartate aminotransferase, gamma-glutamyl transferase (GGT), total bilirubin, prothrombin time, and activated partial thromboplastin time. In addition, serum GAL-3 levels were measured by ELISA technique.

RESULTS: Significantly higher serum GAL-3 levels (16.5±3.6, 1.1±0.3, 0.7±0.5 ng/ml, respectively, p<0.001) and ALT levels (80.2±30.6, 26.8±12.6, 28.1±4.4 IU/L, respectively, p<0.001) were found in the CHB group compared with the inactive carriers and the control groups. There were no significant differences in ALT levels and GAL-3 levels or between inactive HBV carriers and the control groups (p>0.05, for each). Significantly higher GGT levels were found in the CHB group (51.3±27.5 IU/L) compared with the inactive HBV carriers (35.7±10.1 IU/L) and the control group (31.3±9.5 IU/L) (p<0.001, and p=0.004, respectively). A significant correlation was found between GAL-3 and ALT levels in the CHB group (r=0.82, p<0.001).

CONCLUSIONS: Our results suggest that serum GAL-3 level may be a beneficial indicator of chronicity in hepatitis B infection in children.

Keywords: Alanine Transaminase - blood, Adolescent, Aspartate Aminotransferases - blood, Biomarkers - blood, Blood Glucose - analysis, Carrier State - diagnosis, Child, Diagnosis, Differential, Enzyme-Linked Immunosorbent Assay, Galectin 3 - blood, Hepatitis B, Chronic - diagnosis, Hyperbilirubinemia - blood, Partial Thromboplastin Time, Prothrombin Time, Serum Albumin - analysis, gamma-Glutamyltransferase - blood

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750