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Medical Science Monitor Basic Research


eISSN: 1643-3750

Impact of Extracardiac Findings during Cardiac MR on Patient Management and Outcome

Vincent Dunet, Heloise Barras, Xavier Boulanger, Pierre Monney, Salah D. Qanadli, Reto Meuli, Juerg Schwitter, Catherine Beigelman-Aubry

Department of Radiology, Division of Radiodiagnostics and interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland

Med Sci Monit 2015; 21:1288-1296

DOI: 10.12659/MSM.893599

Available online:

Published: 2015-05-06


Background: Cardiac magnetic resonance (CMR) is increasingly used to assess heart diseases. Relevant non-cardiac diseases may also be incidentally found on CMR images. The aim of this study was to determine the prevalence and nature of incidental extra-cardiac findings (IEF) and their clinical impact in non-selected patients referred for CMR.
Material and Methods: MR images of 762 consecutive patients (515 men, age: 56±18 years) referred for CMR were prospectively interpreted by 2 radiologists blinded for any previous imaging study. IEFs were classified as major when requiring treatment, follow-up, or further investigation. Clinical follow-up was performed by checking hospital information records and by calling referring physicians. The 2 endpoints were: 1) non-cardiac death and new treatment related to major IEFs, and 2) hospitalization related to major IEFs during follow-up.
Results: Major IEFs were proven in 129 patients (18.6% of the study population), 14% of those being unknown before CMR. During 15±6 month follow-up, treatment of confirmed major IEFs was initiated in 1.4%, and no non-cardiac deaths occurred. Hospitalization occurred in 8 patients (1.0% of the study population) with confirmed major IEFs and none occurred in the remaining 110 patients with unconfirmed/unexplored major IEFs (p<0.001).
Conclusions: Screening for major IEFs in a population referred for routine CMR changed management in 1.4% of patients. Major IEFs unknown before CMR but without further exploration, however, carried a favorable prognosis over a follow-up period of 15 months.

Keywords: Adult, Adolescent, Aged, 80 and over, Child, Child, Preschool, Disease Management, Hospitalization, Incidental Findings, Kidney Diseases - pathology, Liver Diseases - pathology, Lung Diseases - pathology, Magnetic Resonance Imaging, Myocardium - pathology, Prospective Studies, Single-Blind Method, Spinal Diseases - pathology, Survival Analysis, young adult