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eISSN: 1643-3750

[Retracted]  Effects of Bariatric Surgery on Incidence of Obesity-Related Cancers: A Meta-Analysis

Xiang-wu Yang, Peng-zhou Li, Li-yong Zhu, Shaihong Zhu

Third Xiangya Hospital, Centre South University, Changsha, Hunan, China (mainland)

Med Sci Monit 2015; 21:1350-1357

DOI: 10.12659/MSM.893553

Available online:

Published: 2015-05-11


#893553

BACKGROUND: The aim of this meta-analysis was to investigate possible relationships between bariatric surgery and incidence of obesity-related cancers. Obesity is an established risk factor for obesity-related cancers but the effects of bariatric surgery on incidence of obesity-related cancers are uncertain.
MATERIAL AND METHODS: We searched 4 electronic databases to identify eligible studies: PubMed, Embase, Web of Science, and Google Scholar. Five observational studies were eligible and included in this meta-analysis. Random-effects or fixed-effects odds ratio (OR) and its corresponding 95% confidence interval (CI) were pooled.
RESULTS: Meta-analysis of these 5 observational studies revealed that bariatric surgery was associated with a significantly (p=0.0004) reduced incidence of obesity-related cancers (OR=0.43, 95%CI, 0.27–0.69) when compared with control individuals. Pooled estimated data showed that bariatric surgery is associated with a 24% lower colorectal cancer (CRC) risk. No publication bias was detected by Egger’s or Begg’s tests.
CONCLUSIONS: Although bariatric surgery may significantly reduce incidence of obesity-related cancers, considering the limitations of these included studies, these findings should be confirmed by further well-designed studies.

Keywords: Cohort Studies, Bariatric Surgery, Colorectal Neoplasms - prevention & control, Confounding Factors (Epidemiology), Data Accuracy, Disease Susceptibility, Incidence, Neoplasms - prevention & control, Obesity, Morbid - surgery, Observational Studies as Topic - statistics & numerical data, Publication Bias




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