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12 February 2015 : Clinical Research  

Abnormal Functional Connectivity of the Amygdala-Based Network in Resting-State fMRI in Adolescents with Generalized Anxiety Disorder

Wen-jing LiuAEF, Da-zhi YinCE, Wen-hong ChengAE, Ming-xia FanDF, Mei-na YouDG, Wei-wei MenBC, Li-li ZangBD, Dian-hong ShiG, Fang ZhangG

DOI: 10.12659/MSM.893373

Med Sci Monit 2015; 21:459-467


BACKGROUND: We aimed to investigate the disruptions of functional connectivity of amygdala-based networks in adolescents with untreated generalized anxiety disorder (GAD).

MATERIAL AND METHODS: A total of 26 adolescents with first-episode GAD and 20 normal age-matched volunteers underwent resting-state and T1 functional magnetic resonance imaging (fMRI). We analyzed the correlation of fMRI signal fluctuation between the amygdala and other brain regions. The variation of amygdala-based functional connectivity and its correlation with anxiety severity were investigated.

RESULTS: Decreased functional connectivity was found between the left amygdala and left dorsolateral prefrontal cortex. An increased right amygdala functional connectivity with right posterior and anterior lobes of the cerebellum, insula, superior temporal gyrus, putamen, and right amygdala were found in our study. Negative correlations between GAD scores and functional connectivity of the right amygdala with the cerebellum were also observed in the GAD adolescents.

CONCLUSIONS: Adolescents with GAD have abnormalities in brain regions associated with the emotional processing pathways.

Keywords: Amygdala - physiology, Adolescent, Anxiety Disorders - pathology, China, Emotions - physiology, Magnetic Resonance Imaging, Nerve Net - abnormalities, Prefrontal Cortex - physiology, Questionnaires



01 January 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750