Logo MSM

26 April 2015 : Clinical Research

Effects of Olmesartan on Endothelial Progenitor Cell Mobilization and Function in Carotid Atherosclerosis

Xin GongDE, Li ShaoFG, Yi-Min FuDE, Yong ZouABC

Med Sci Monit 2015; 21:1189-1193


BACKGROUND: Olmesartan is a type of angiotensin II receptor inhibitor that can reduce the incidence of cardiovascular events. However, its role in the function of endothelial progenitor cells in atherosclerosis patients is still unclear. Our study aimed to explore the effects and mechanism of olmesartan on endothelial progenitor cell mobilization and function in carotid atherosclerosis.

MATERIAL AND METHODS: Forty carotid atherosclerosis patients were enrolled. Patients were administrated olmesartan 20 mg/day for 3 months. Flow cytometry was used for counting circulating endothelial progenitor cells; colorimetric method was used to measure the serum levels of endothelial nitric oxide synthase and nitric oxide. Cell migration, adhesion, and proliferation capacity, and related signaling pathway were also analyzed. Spearman rank correlation analysis was used to investigate the influence of olmesartan on endothelial progenitor cells and clinical characteristics (e.g., sex, age, blood pressure).

RESULTS: Compared with the control group, the number of circulating endothelial progenitor cells was significantly decreased. Olmesartan can increase circulating endothelial progenitor cells number and the serum levels of eNOS and NO. Furthermore, it can improve cell migration, adhesion, and proliferation capacities. Spearman rank correlation analysis showed there is no relationship between olmesartan promotion effects on endothelial progenitor cell mobilization and the clinical characteristics (P>0.05). P-eNOS and P-Akt expression can be unregulated by RNH-6270 treatment and blocked by LY294002.

CONCLUSIONS: Olmesartan can effectively promote the endothelial progenitor cells mobilization and improve their function in patients with carotid atherosclerosis, independent of basic characteristics. This process relies on the PI3K/Akt/eNOS signaling pathway.

Keywords: Angiotensin II Type 1 Receptor Blockers - therapeutic use, Adult, Carotid Artery Diseases - physiopathology, Case-Control Studies, Cell Adhesion - drug effects, Cell Count, Cell Movement - drug effects, Cell Proliferation - drug effects, Endothelial Progenitor Cells - physiology, Imidazoles - therapeutic use, Nitric Oxide - blood, Nitric Oxide Synthase Type III - blood, Signal Transduction - drug effects, Tetrazoles - therapeutic use


This Week Editorial

02 August 2021 : Editorial

Editorial: The National COVID Cohort Collaborative Consortium Combines Population Data with Machine Learning to Evaluate and Predict Risk Factors for the Severity of COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934171

Med Sci Monit 2021; 27:e934171

Coronavirus/Covid 19

30 July 2021 : Clinical Research

Rural and Female Patients with Old Myocardial Infarction Lacked Knowledge and Preventive Measures During th...

Med Sci Monit In Press  ::  DOI: 10.12659/MSM.928512  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press  ::  DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press  ::  DOI: 10.12659/MSM.931467  

07 July 2021 : Database Analysis

Chest Radiological Findings and Clinical Characteristics of Laboratory-Confirmed COVID-19 Patients from Sau...

Med Sci Monit In Press  ::  DOI: 10.12659/MSM.932441  

In Press

03 Aug 2021 : Clinical Research

Comparison of Outcomes Following TiRobot-Assisted Sacroiliac Screw Fixation with Bone Grafting and Traditio...

Med Sci Monit In Press  ::  DOI: 10.12659/MSM.932724  

02 Aug 2021 : Database Analysis

RNA N6-Methyladenosine Patterns in Hepatocellular Carcinoma Reveal a Distinct Immune Infiltration Landscape...

Med Sci Monit In Press  ::  DOI: 10.12659/MSM.930994  

02 Aug 2021 : Clinical Research

Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children

Med Sci Monit In Press  ::  DOI: 10.12659/MSM.932518  

30 Jul 2021 : Clinical Research

Rural and Female Patients with Old Myocardial Infarction Lacked Knowledge and Preventive Measures During th...

Med Sci Monit In Press  ::  DOI: 10.12659/MSM.928512  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750