Zongcheng Wang, Yuren Jiang, Xi Wang, Yangsen Du, Dandan Xiao, Youchao Deng, Jinlian Wang
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, China (mainland)
Med Sci Monit 2015; 21:1408-1413
Although many studies have estimated the association between the butyrylcholinesterase (BCHE) K variant and Alzheimer’s disease (AD) risk, the results are still controversial. We thus conducted this meta-analysis.
Material and Methods: We searched NCBI, Medline, Web of Science, and Embase databases to find all eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.
Results: We found a significant association between BCHE K variant and AD risk (OR=1.20; 95% CI 1.03–1.39; P=0.02). In the stratified analysis by ethnicity, we observed a significant association between BCHE K variant and AD risk in Asians (OR=1.32; 95% CI 1.02–1.72; P=0.04). However, no significant association between BCHE K variant and AD risk in Caucasians was found (OR=1.14; 95% CI 0.95–1.37; P=0.16). When stratified by the age of AD onset, we found that late-onset AD (LOAD) was significantly associated with BCHE K variant (OR=1.44; 95% CI 1.05–1.97; P=0.02). No significant association between BCHE K variant and early-onset AD (EOAD) risk was observed (OR=1.16; 95% CI 0.89–1.51; P=0.27). Compared with non-APOE ε4 and non-BCHE K carriers, no significant association between BCHE K variant and AD risk was found (OR=1.11; 95% CI 0.91–1.35; P=0.30). However, APOE ε4 carriers showed increased AD risk in both non-BCHE K carriers (OR=2.81; 95% CI 1.75–4.51; P=0.0001) and BCHE K carriers (OR=3.31; 95% CI 1.82–6.02; P=0.0001).
Conclusions: The results of this meta-analysis indicate that BCHE K variant might be associated with AD risk.
Keywords: Aged, Age of Onset, Aged, 80 and over, Alzheimer Disease - genetics, Apolipoprotein E4 - genetics, Asian Continental Ancestry Group - genetics, Butyrylcholinesterase - genetics, European Continental Ancestry Group - genetics, Female, Genetic Predisposition to Disease, Humans, Male, Odds Ratio, Polymorphism, Single Nucleotide, Publication Bias, Risk, Sensitivity and Specificity