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17 June 2015 : Clinical Research  

Efficacy and Safety of Continuous Micro-Pump Infusion of 3% Hypertonic Saline combined with Furosemide to Control Elevated Intracranial Pressure

Yuqian LiABCDEF, Zhihong LiABCDEF, Min LiBD, Yanlong YangBD, Bao Wang, Li GaoBCD, Xingye ZhangBD, Hongyu ChengBD, Wei FangABD, Bo ZhaoB, Boliang WangBCD, Guodong GaoBCD, Lihong LiCDEF

DOI: 10.12659/MSM.892924

Med Sci Monit 2015; 21:1752-1758

Abstract

BACKGROUND: Elevated intracranial pressure is one of the most common problems in patients with diverse intracranial disorders, leading to increased morbidity and mortality. Effective management for increased intracranial pressure is based mainly on surgical and medical techniques with hyperosmolar therapy as one of the core medical treatments. The study aimed to explore the effects of continuous micro-pump infusions of 3% hypertonic saline combined with furosemide on intracranial pressure control.

MATERIAL AND METHODS: We analyzed data on 56 eligible participants with intracranial pressure >20 mmHg from March 2013 to July 2014. The target was to increase and maintain plasma sodium to a level between 145 and 155 mmol/L and osmolarity to a level of 310 to 320 mOsmol/kg.

RESULTS: Plasma sodium levels significantly increased from 138±5 mmol/L at admission to 151±3 mmol/L at 24 h (P<0.01). Osmolarity increased from 282±11 mOsmol/kg at baseline to 311±8 mOsmol/kg at 24 h (P<0.01). Intracranial pressure significantly decreased from 32±7 mmHg to 15±6 mmHg at 24 h (P<0.01). There was a significant improvement in CPP (P<0.01). Moreover, central venous pressure, mean arterial pressure, and Glasgow Coma Scale slightly increased. However, these changes were not statistically significant.

CONCLUSIONS: Continuous infusion of 3% hypertonic saline + furosemide is effective and safe for intracranial pressure control.

Keywords: Brain Injuries - physiopathology, Furosemide - adverse effects, Infusion Pumps, Intracranial Hypertension - drug therapy, Osmolar Concentration, Saline Solution, Hypertonic - adverse effects, Sodium - blood

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750