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Medical Science Monitor Basic Research


eISSN: 1643-3750

Interferon-γ +874A/T Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis

Huan Zhou, Lizhou Wang, Xing Li, Jie Song, Tianpeng Jiang, Xiaoping Wu, Shi Zhou

Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, China (mainland)

Med Sci Monit 2015; 21:689-693

DOI: 10.12659/MSM.892885

Available online:

Published: 2015-03-05


Background: Studies have evaluated the association between interferon-γ (IFN-γ) +874A/T polymorphism and hepatocellular carcinoma (HCC) risk, but the results are controversial. We performed this meta-analysis to further investigate this association.
Material and Methods: Relevant studies were searched by using the PubMed, Web of Science, and Embase databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. Subgroup analysis and sensitivity analysis were conducted.
Results: Seven case-control studies (859 HCC patients and 1482 healthy controls) were identified to assess the association between IFN-γ +874A/T polymorphism and risk of HCC. IFN-γ +874A/T polymorphism was significantly associated with an increased risk of HCC (OR=1.38; 95% CI 1.12–1.70; P=0.002). In the subgroup analysis by ethnicity, IFN-γ +874A/T polymorphism was significantly associated with HCC risk in Asians (OR=1.42; 95% CI 1.08–1.87; P=0.01), but no significant association was found in Caucasians (OR=1.21; 95% CI 0.86–1.70; P=0.28). IFN-γ +874A/T polymorphism also increased HBV-induced HCC risk (OR=1.42; 95% CI 1.08–1.87; P=0.01). In the subgroup analysis by control source, IFN-γ +874A/T polymorphism was associated with HCC risk in hospital-based studies (OR=1.45; 95% CI 1.09–1.53; P=0.01). A marginal association was found in population-based studies (OR=1.33; 95% CI 0.97–1.83; P=0.08).
Conclusions: This meta-analysis indicates that the IFN-γ +874A/T polymorphism might contribute to HCC risk.

Keywords: Genetic Association Studies, Carcinoma, Hepatocellular - genetics, Genetic Predisposition to Disease, Interferon-gamma - genetics, Liver Neoplasms - genetics, Polymorphism, Single Nucleotide - genetics, Risk Factors