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16 March 2015 : Laboratory Research

Expression and Clinical Significance of microRNA-1246 in Human Oral Squamous Cell Carcinoma

Lan LiaoABDE, Jun WangBC, Shaobo OuyangBF, Peng ZhangB, Jiaolong WangC, Meng ZhangAEG

DOI: 10.12659/MSM.892508

Med Sci Monit 2015; 21:776-781

Abstract

BACKGROUND: MicroRNAs (miRNAs) are small, non-coding RNAs that may function as oncogenes or tumor suppressors. Previous studies have shown that the expression level of miR-1246 was enhanced in multiple types of cancers. However, the expression of miR-1246 in human oral squamous cell carcinoma (OSCC) and its prognostic values remain unclear.

MATERIAL AND METHODS: Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to analyze the expression of miR-1246 in 106 pairs of matched normal and tumor tissue samples. The chi-square test was used to examine the associations between miR-1246 expression and the clinicopathological characters. The survival curves were constructed by the Kaplan-Meier method. The influence of each clinical variable on survival was examined by the Cox multivariate regression analysis.

RESULTS: The expression level of miR-1246 was significantly higher in tumor tissues and oral cancer cell lines than in normal controls (p<0.01). High expression of miR-1246 was found to significantly correlate with nodal status (p=0.015), TNM stage (p=0.005), and tumor grade (p=0.002). Enhanced miR-1246 correlated significantly with patient survival (p<0.01). In multivariate analysis, we found that miR-1246 expression was an independent prognostic factor of poor patient survival (p= 0.036; HR=2.82; 95% CI=1.07–7.43).

CONCLUSIONS: High miR-1246 expression is associated with poor prognosis in OSCC and may serve as a novel prognostic marker in OSCC.

Keywords: Carcinoma, Squamous Cell - pathology, Case-Control Studies, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, MicroRNAs - metabolism, Mouth Neoplasms - pathology, Multivariate Analysis, Prognosis, Real-Time Polymerase Chain Reaction

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750