Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

29 September 2014 : Original article  

Polymorphism Ala54Thr of Fatty Acid-Binding Protein 2 Gene is Not Associated with Stroke Risk in Han Population of Hunan China

Yanmin SongABCDEF, Yinxi LongABCDF, Lili LongCDE, Ning ZhangCDE, Yunhai LiuABCDEFG

DOI: 10.12659/MSM.892226

Med Sci Monit 2014; 20:1751-1757

Abstract

BACKGROUND: The aim of this study is to make sure whether polymorphism Ala54Thr of gene Fatty Acid-Binding Protein 2 (FABP2) is associated with stroke risk in Hunan Han population of China.

MATERIAL AND METHODS: A total of 206 cerebral infarction (CI), 185 cerebral hemorrhage (CH) and 172 controls were enrolled in our study. Ala54Thr was applied by polymerasechain reaction (PCR) and restriction fragment length polymorphism (RFLP).

RESULTS: No significant difference in Ala54Thr genotypic distribution of FABP2 was observed between stroke group (CI subgroup, CH subgroup included) and controls group. In stroke group, plasma TG level of who carried Ala54Thr, Thr54Thr of FABP2 is significantly higher than who carring Ala54Ala. In controls group, blood lipid is not significantly different among 3 genotypes of Ala54Thr. There is no significant difference in blood pressure and fasting blood sugar between strokes and controls.

CONCLUSIONS: Our study shows that Ala54Thr of FABP2 may be not associated with stroke risk but associated with plasma TG level of stroke patients for Hunan Han population of China.

Keywords: Demography, China, Case-Control Studies, Amino Acid Substitution, Ethnic Groups - genetics, Fatty Acid-Binding Proteins - genetics, Gene Frequency - genetics, Genetic Association Studies, Genetic Predisposition to Disease, Logistic Models, Polymorphism, Single Nucleotide - genetics, Risk Factors, Stroke - genetics

0 Comments

Editorial

01 December 2021 : Editorial  

Editorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19

Dinah V. Parums
Scientific Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.935624

Med Sci Monit 2021; 27:e935624

SARS-CoV-2/COVID-19

03 December 2021 : Laboratory Research  

Influenza and Influenza-Like Respiratory Virus Infections in Children During the 2019/20 Influenza Season a...

Med Sci Monit In Press; DOI: 10.12659/MSM.934862  

08 November 2021 : Database Analysis  

Virtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Cor...

Med Sci Monit In Press; DOI: 10.12659/MSM.934102  

01 December 2021 : Editorial  

Editorial: SARS-CoV-2 Vaccine Responses and Breakthrough COVID-19

Med Sci Monit 2021; 27:e935624

In Press

03 Dec 2021 : Clinical Research  

A Retrospective Single-Center Study of 23 Patients to Compare Gait Before and After Total Hip Arthroplasty ...

Med Sci Monit In Press; DOI: 10.12659/MSM.934558  

03 Dec 2021 : Laboratory Research  

Influenza and Influenza-Like Respiratory Virus Infections in Children During the 2019/20 Influenza Season a...

Med Sci Monit In Press; DOI: 10.12659/MSM.934862  

02 Dec 2021 : Clinical Research  

Comparison of Outcomes Following Neuronavigation-Assisted Aspiration and Thrombolysis Using Single and Mult...

Med Sci Monit In Press; DOI: 10.12659/MSM.934935  

02 Dec 2021 : Clinical Research  

Serum Levels of N-Terminal Pro-Brain Natriuretic Peptide in Gestational Hypertension, Mild Preeclampsia, an...

Med Sci Monit In Press; DOI: 10.12659/MSM.934285  

Most Viewed Current Articles

20 Mar 2020 : Clinical Research  

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research  

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article  

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research  

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750