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28 September 2014 : Original article

Gene Polymorphisms of Adducin GLY460TRP, ACE I/D, AND AGT M235T in Pediatric Hypertension Patients

İbrahim KaplanAE, Enver SancaktarB, Aydın EceCF, Velat ŞenDG, Nilgün TekkeşinD, Mustafa Kemal BasaraliF, Selvi KelekciA, Osman EvliyaogluF

DOI: 10.12659/MSM.892140

Med Sci Monit 2014; 20:1745-1750

Abstract

BACKGROUND: Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension.

MATERIAL AND METHODS: Included in the study were 58 hypertensive and 58 normotensive pediatric patients. ACE I/D and AGT M235T polymorphisms are determined by conventional PCR; ADD Gly460Trp polymorphism was investigated using PCR amplification of genomic DNA.

RESULTS: There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.

CONCLUSIONS: We suggest that RAS gene polymorphisms (ACE-I/D, AGT M235T) are significantly associated with susceptibility to diseases that lead to secondary hypertension.

Keywords: Angiotensinogen - genetics, Alleles, Calmodulin-Binding Proteins - genetics, Case-Control Studies, Child, Gene Frequency, Genetic Predisposition to Disease, Hypertension - genetics, Peptidyl-Dipeptidase A - genetics, Polymorphism, Single Nucleotide - genetics, Renal Insufficiency, Chronic - genetics

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