10 January 2015 : Clinical Research
Med Sci Monit 2015; 21:118-122
BACKGROUND: Inflammation is involved in the mechanism of inflammatory bowel disease (IBD). Omentin, a newly discovered adipokine, is thought to play an anti-inflammatory role. This study aimed to determine whether serum levels of omentin-1 are associated with the presence and disease activity of IBD.
MATERIAL AND METHODS: This study consisted of 192 patients with IBD: 100 with Crohn’s disease [CD], 92 with ulcerative colitis [UC], and 104 healthy subjects. Serum levels of omentin-1 were measured using enzyme-linked immunosorbent assay (ELISA).
RESULTS: Serum omentin-1 levels were significantly decreased in CD and UC patients compared with healthy controls. Multivariable logistic regression analysis revealed that serum omentin-1 levels were inversely associated with the presence of CD and UC. Active CD and UC patients both had significantly decreased levels of serum omentin-1 compared with inactive CD and UC patients. In both CD and UC patients, serum omentin-1 levels were significantly associated with decreased levels of body mass index (BMI) and C-reactive protein (CRP).
CONCLUSIONS: Decreased serum omentin-1 levels could be considered as an independent predicting marker of the presence and disease activity of IBD.
Keywords: Adipokines - metabolism, Anti-Inflammatory Agents - chemistry, Biological Markers - blood, Body Mass Index, C-Reactive Protein - metabolism, Case-Control Studies, Colitis, Ulcerative - blood, Crohn Disease - blood, Cross-Sectional Studies, Cytokines - blood, Enzyme-Linked Immunosorbent Assay, GPI-Linked Proteins - blood, Gene Expression Regulation, Lectins - blood, Logistic Models
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