14 February 2015 : Animal Research
Dioscorea batatas Extract Attenuates High-Fat Diet-Induced Obesity in Mice by Decreasing Expression of Inflammatory CytokinesHyo-Wook GilABCDEF, Eun-Young LeeACDF, Ji-Hye LeeBCD, Yong-Sik KimACDF, Byung-Eui LeeABCDF, Jeong Woo SukDFG, Ho-Yeon SongADEFG
Med Sci Monit 2015; 21:489-495
BACKGROUND: The objective of the present study was to determine whether Dioscorea batatas (DB) extract reduces visceral fat accumulation and obesity-related biomarkers in mice fed a high-fat diet (HFD) and whether genes associated with adipogenesis and inflammation could be modulated by a diet containing DB extract.
MATERIAL AND METHODS: Male C57BL/6J mice were divided into 4 groups (n=10 per group): normal diet (ND), HFD, 100 mg/kg DB extract-gavage with HFD, and 200 mg/kg DB extract-gavage with HFD. The mice were fed the experimental diets for 14 weeks. At 12 weeks, micro-computed X-ray tomography (micro-CT) was performed.
RESULTS: Supplementation of the diet with DB extract for 14 weeks significantly prevented HFD-induced increases in body weight, visceral adipose tissue, plasma lipid levels, and leptins. The area of visceral fat was reduced by DB extract supplementation when examined by micro-CT. Supplementation with DB extract resulted in the downregulation of the adipogenic transcription factor (C/ERBa) and its target gene (CD36) in epididymal adipose tissue, compared to HFD alone. DB extract decreased the expression of proinflammatory cytokines (TNF-α, MCP-1, and IL-6) in epididymal adipose tissue.
CONCLUSIONS: Our results suggest that DB extract may prevent HFD-induced obesity by downregulating the expression of genes related to adipogenesis and inflammation in visceral adipose tissue.
Keywords: Animals, Adipogenesis - drug effects, Biological Markers - metabolism, Body Weight - drug effects, Cytokines - metabolism, Diet, High-Fat, Dioscorea - chemistry, Gene Expression Regulation - drug effects, Intra-Abdominal Fat - drug effects, Mice, Mice, Inbred C57BL, Obesity - etiology, Plant Extracts - pharmacology, Thyroid Hormone Receptors alpha - metabolism, X-Ray Microtomography
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