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13 October 2014 : Original article  

Bamboo Joint-Like Appearance of the Stomach: A Stable Endoscopic Landmark for Crohn’s Disease Regardless of Anti-Tumor Necrosis Factor alpha Treatment

Keiichi HashiguchiBCEF, Fuminao TakeshimaABCEF, Yuko AkazawaDE, Kayoko MatsushimaBD, Hitomi MinamiB, Naoyuki YamaguchiB, Ken ShiozawaD, Ken OhnitaC, Tatsuki IchikawaCD, Hajime IsomotoDE, Kazuhiko NakaoEG

DOI: 10.12659/MSM.891060

Med Sci Monit 2014; 20:1918-1924

Abstract

BACKGROUND: Bamboo joint-like appearance is a common yet easy-to-miss endoscopic finding in the stomach of patients with Crohn’s disease (CD). Bamboo joint-like appearance (BJA) is characterized by swollen longitudinal folds transversed by erosive fissures or linear furrows. However, whether BJA is observed during the remission stage of CD and during the active stage is unclear. In particular, the relationship between the course of BJA and anti-tumor necrosis factor (TNF) α therapy has not been studied. We aimed to evaluate the course of BJA in CD patients treated with anti-TNF α therapy.

MATERIAL AND METHODS: We examined 22 CD patients who underwent esophagogastroduodenal endoscopy before undergoing anti-TNF α treatment. We evaluated the changes in BJA, clinical activity using the CD activity index (CDAI), and endoscopic activity using the simple endoscopic score for CD (SES-CD) from 6 months to 1 year after anti-TNF α therapy.

RESULTS: Fifteen of 22 patients (68.1%) presented with BJA in the stomach, 13 of whom received follow-up esophagogastroduodenal endoscopy after anti-TNF α therapy. The mean CDAI and SES-CD scores significantly improved after anti-TNF α therapy (P<0.01). Despite the marked improvements in clinical and endoscopic findings, the BJA of the stomach remained unchanged in all the patients.

CONCLUSIONS: The findings indicate that BJA is frequently observed in the stomach of CD patients, regardless of whether the patient has active disease or is in remission, even after anti-TNF α therapy. Thus, BJA may be a stable endoscopic landmark in CD.

Keywords: Crohn Disease - therapy, Stomach - pathology, Tumor Necrosis Factor-alpha - antagonists & inhibitors

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750