18 December 2014 : Original article
Relationship between Initial Lens Transparency and Ocular Circulation in Adolescents with Type-1 Diabetes Mellitus, Unstable Glycaemia and Lipid ParametersMonika ModrzejewskaADEF, Wilhelm GrzesiakCF, Daniel ZaborskiCF, Grażyna WilkDF, Anna ModrzejewskaBF
Pol J Radiol 2014; 79:472-478
BACKGROUND: The aim of this study was to determine the relationships between lens opacity, vascular and lipid factors and retrobulbar blood flow parameters in type-1 diabetic (DM) adolescents.
MATERIAL AND METHODS: Glycated haemoglobin (HbA1c), total cholesterol (TCH), high- and low-density cholesterol, triglycerides (TG) and apolipoprotein B (ApoB) were determined in 28 patients with (DM-1) and without (DM-0) lens opacity and 18 controls. In the ophthalmic, central retinal (CRA) and temporal posterior ciliary (TPCA) arteries, the systolic (PSV), end-diastolic and mean blood flow velocities as well as pulsatility and resistance (RI) indices were measured.
RESULTS: Ten (35.71%) diabetic patients exhibited lens opacification. Higher TG and TCH levels in the DM-1 group and HbA1c level in the DM-0 and DM-1 groups were observed (P≤0.05). Diabetic patients had lower PSV and higher RI within CRA and TPCA (P£0.05). Significant correlations between biochemical and blood flow parameters were found.
CONCLUSIONS: Glycaemic and lipid factors may play a vasoconstrictive role in retrobulbar endotheliopathy.
Keywords: Cataract, Diabetes Mellitus, Type 1, dyslipidemias, Hemoglobin A, Glycosylated
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