04 August 2014 : Original article
Importance of Metastatic Lymph Node Ratio in Non-Metastatic, Lymph Node-Invaded Colon Cancer: A Clinical Trial
Arda IsikABCDEF, Kemal PekerABCDEF, Deniz FiratABCDEF, Bahri YilmazABCDEF, Ilyas SayarABD, Oguz IdizAB, Coskun CakirAB, Ismail DemiryilmazAB, Ismayil YilmazABDOI: 10.12659/MSM.890804
Med Sci Monit 2014; 20:1369-1375
Abstract
BACKGROUND: The aim of this study was to evaluate the prognostic importance of the metastatic lymph node ratio for stage III colon cancer patients and to find a cut-off value at which the overall survival and disease-free survival change.
MATERIAL AND METHODS: Patients with pathological stage III colon cancer were retrospectively evaluated for: age; preoperative values of Crp, Cea, Ca 19-9, and Afp; pathologic situation of vascular, perineural, lymphatic, and serosal involvement; and metastatic lymph node ratio values were calculated.
RESULTS: The study included 58 stage III colon cancer patients: 20 (34.5%) females and 38 (65.5%) males were involved in the study. Multivariate analysis was applied to the following variables to evaluate significance for overall survival and disease-free survival: age, Crp, Cea, perineural invasion, and metastatic lymph node ratio. The metastatic lymph node ratio (<0.25 or ≥0.25) is the only independent variable significant for overall and disease-free survival.
CONCLUSIONS: Metastatic lymph node ratio is an ideal prognostic marker for stage III colon cancer patients, and 0.25 is the cut-off value for prognosis.
Keywords: Colonic Neoplasms - physiopathology, Disease-Free Survival, Lymphatic Metastasis - pathology, Multivariate Analysis, Neoplasm Invasiveness - pathology, Prognosis, Tumor Markers, Biological
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