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02 September 2014 : Original article

Multi-Slice Computed Tomography 5-Minute Delayed Scan is Superior to Immediate Scan after Contrast Media Application in Characterization of Intracranial Tuberculosis

Dailun HouAB, Huifang QuBC, Xu ZhangCD, Ning LiAB, Cheng LiuEF, Xiangxing MaAF

DOI: 10.12659/MSM.890719

Med Sci Monit 2014; 20:1556-1562

Abstract

BACKGROUND: The aim of this study was to determine whether the diagnosis of intracranial tuberculosis (TB) can be improved when multi-slice computed tomography (MSCT) scans are taken with a 5-min delay after contrast media application.

MATERIAL AND METHODS: Pre- and post-contrast CT scans of the head were obtained from 30 patients using a 16-slice spiral CT. Dual-phase acquisition was performed immediately and 5 min after contrast agent injection. Diagnostic values of different images were compared using a scoring system applied by 2 experienced radiologists.

RESULTS: We found 526 lesions in 30 patients, including 22 meningeal thickenings, 235 meningeal tuberculomas/tubercles, and 269 parenchymal tuberculomas/tubercles. Images obtained with 5-min delayed scan time were superior in terms of lesion size and meningeal thickening outlining in all disease types (P<0.01). The ability to distinguish between vascular sections from the cerebral sulcus and tubercle was also improved (P<0.01).

CONCLUSIONS: Image acquisition with 5-min delay after contrast agent injection should be performed as a standard scanning protocol to diagnose intracranial TB.

Keywords: Child, Adult, Adolescent, Contrast Media - diagnostic use, Meninges - radiography, Multidetector Computed Tomography - methods, Time Factors, Tuberculoma, Intracranial - radiography, young adult

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750