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10 June 2014 : Review article

Clinical application of adoptive T cell therapy in solid tumors

Yi-Wen ZangAEF, Xiao-Dong GuAEFG, Jian-Bin XiangEF, Zong-You ChenEF

DOI: 10.12659/MSM.890496

Med Sci Monit 2014; 20:953-959

Abstract

ABSTRACT: As an emerging therapeutic approach, adoptive T cell therapy shown promise in advanced solid malignancies. The results obtained in patients with metastatic melanoma and kidney cancer are encouraging because of the visible clinical benefits and limited adverse effects. Recently, the genetically-modified T cells expressing specific T cell receptors or chimeric antigen receptors are just now entering the clinical arena and show great potential for high avidity to tumor-associated antigens and long-lasting anti-tumor responses. However, continued investigations are necessary to improve the cell product quality so as to decrease adverse effects and clinical costs, and make adoptive T cell therapy a tool of choice for solid malignancies.

Keywords: Clinical Trials as Topic, Adoptive Transfer, Neoplasms - therapy, T-Lymphocytes - immunology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750