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18 July 2014 : Review article  

Meta-analysis of GSTM1 null genotype and lung cancer risk in Asians

Xiaomin LiuABCDEF, Zhijuan LiABCDEF, Zhiye ZhangABCDEF, Weimin ZhangABCDEF, Wei LiABCDEF, Zhongyue XiaoABCDEF, Huazhuan LiuABCDEF, Hongduo JiaoABCDEF, Yi WangABCDEF, Guoguo LiABCDEF

DOI: 10.12659/MSM.890490

Med Sci Monit 2014; 20:1239-1245

Abstract

Background
Several molecular epidemiological studies have been conducted to examine the association between glutathione S-transferase M 1 (GSTM1) null genotype and lung cancer in Asians; however, the conclusions remained controversial. We therefore performed an extensive meta-analysis on 31 published case-control studies with a total of 5347 lung cancer cases and 6072 controls.
Material and Methods
PubMed and EMBASE were searched to identify case-control studies investigating the associations of GSTM1 null genotype with risk of lung cancer in Asians. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between lung cancer risk and polymorphism of GSTM1.
Results
GSTM1 null genotype was significantly associated with lung cancer risk (OR=1.43; 95% CI, 1.30–1.58). This result remained statistically significant when the adjusted ORs were combined (OR=1.38; 95% CI, 1.23–1.54). In the subgroup analysis by sex, there were significant associations in women and men. When stratifying for histology, this genotype showed increased adenocarcinoma risk and squamous cell carcinoma risk. In the subgroup analysis stratified by smoking status, lung cancer risk was increased in both smokers and non-smokers.
Conclusions
This study suggests that GSTM1 null genotype is a risk factor for lung cancer in Asians.

Keywords: Case-Control Studies, Asian Continental Ancestry Group - genetics, Genotype, Glutathione Transferase - genetics, Lung Neoplasms - genetics, Odds Ratio, Risk Factors

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750