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Medical Science Monitor Basic Research


eISSN: 1643-3750

Surgical Management of Early Endometrial Cancer: An Update and Proposal of a Therapeutic Algorithm

Francesca Falcone, Giancarlo Balbi, Luca Di Martino, Flavio Grauso, Maria Elena Salzillo, Enrico Michelino Messalli

Department of Woman, Child, and General and Specialized Surgery, Second University of Naples, Naples, Italy

Med Sci Monit 2014; 20:1298-1313

DOI: 10.12659/MSM.890478

Available online: 2014-07-26

Published: 2014-07-26


Abstract: In the last few years technical improvements have produced a dramatic shift from traditional open surgery towards a minimally invasive approach for the management of early endometrial cancer. Advancement in minimally invasive surgical approaches has allowed extensive staging procedures to be performed with significantly reduced patient morbidity. Debate is ongoing regarding the choice of a minimally invasive approach that has the most effective benefit for the patients, the surgeon, and the healthcare system as a whole.
Surgical treatment of women with presumed early endometrial cancer should take into account the features of endometrial disease and the general surgical risk of the patient. Women with endometrial cancer are often aged, obese, and with cardiovascular and metabolic comorbidities that increase the risk of peri-operative complications, so it is important to tailor the extent and the radicalness of surgery in order to decrease morbidity and mortality potentially derivable from unnecessary procedures. In this regard women with negative nodes derive no benefit from unnecessary lymphadenectomy, but may develop short- and long-term morbidity related to this procedure. Preoperative and intraoperative techniques could be critical tools for tailoring the extent and the radicalness of surgery in the management of women with presumed early endometrial cancer. In this review we will discuss updates in surgical management of early endometrial cancer and also the role of preoperative and intraoperative evaluation of lymph node status in influencing surgical options, with the aim of proposing a management algorithm based on the literature and our experience.

Keywords: Endometrial Neoplasms - surgery, Disease Management, Algorithms, Lymph Node Excision - standards, Minimally Invasive Surgical Procedures - trends, Robotic Surgical Procedures - trends, Tumor Markers, Biological