06 July 2014 : Original article
Serum adenosine deaminase activity in cutaneous anthrax
Mahmut SunnetciogluABCDEF, Sevdegul KaradasABDEF, Mehmet AslanABDEF, Mehmet Resat CeylanABCDEF, Halit DemirABCDE, Mehmet Resit OncuABDEF, Mustafa Kasım KarahocagilABCDE, Aysel SunnetciogluABCDEF, Cenk AypakACDEFDOI: 10.12659/MSM.890472
Med Sci Monit 2014; 20:1151-1154
Abstract
BACKGROUND: Adenosine deaminase (ADA) activity has been discovered in several inflammatory conditions; however, there are no data associated with cutaneous anthrax. The aim of this study was to investigate serum ADA activity in patients with cutaneous anthrax.
MATERIAL AND METHODS: Sixteen patients with cutaneous anthrax and 17 healthy controls were enrolled. We measured ADA activity; peripheral blood leukocyte, lymphocyte, neutrophil, and monocyte counts; erythrocyte sedimentation rate; and C reactive protein levels.
RESULTS: Serum ADA activity was significantly higher in patients with cutaneous anthrax than in the controls (p<0.001). A positive correlation was observed between ADA activity and lymphocyte counts (r=0.589, p=0.021) in the patient group.
CONCLUSIONS: This study suggests that serum ADA could be used as a biochemical marker in cutaneous anthrax.
Keywords: Adult, Adenosine Deaminase - blood, Anthrax - enzymology, Case-Control Studies, Demography, Skin Diseases, Bacterial - enzymology
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