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28 June 2014 : Original article  

Efficacy of glycerol and flax seed oil as anti-adhesive barriers after thyroidectomy

Oguz IdizABCDEF, Erhan AysanABCDEF, Deniz FiratABCDEF, Yeliz Emine ErsoyABCDF, Merve Busra CengizB, Huseyin AkbulutB, Arda IsıkEF, Mahmut MuslumanogluABCD

DOI: 10.12659/MSM.890460

Med Sci Monit 2014; 20:1090-1094

Abstract

BACKGROUND: We evaluated the effects of local flax seed oil and glycerol application for reducing adhesion formation after thyroidectomy.

MATERIAL AND METHODS: We randomly assigned 18 female Wistar albino rats (median weight: 275 g, median age: 4.5 mth) to 3 groups: 0.1 ml 0.9% NaCl, glycerol, and flax seed oil were sprayed in a perithyroidal area after thyroidectomy operation on all animals as anti-adhesive barriers. Rats were sacrificed on the postoperative 14th day and adhesions were evaluated macroscopically and microscopically.

RESULTS: The median macroscopic adhesion score was 3.0±0.0 in the 0.9% NaCl group, 1.33±0.52 in the glycerol group, and 1.67±0.53 in the flax seed oil group. The median histopathological fibrosis scores were 2.33±0.82, 0.67±0.52, and 0.83±0.75, respectively. Both glycerol and flaxseed oil group macroscopic and microscopic scores were significantly lower than the 0.9% NaCl group (p<0.05). There was no significant difference among the groups (p>0.05).

CONCLUSIONS: Glycerol and flax seed oil both decrease the incidence of post-thyroidectomy adhesion in rats, but glycerol is more effective.

Keywords: Glycerol - therapeutic use, Fibrosis, Linseed Oil - therapeutic use, Rats, Wistar, Thyroidectomy - adverse effects, Tissue Adhesions - etiology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750