17 May 2014 : Original article
Down-regulated microRNA-101 in bladder transitional cell carcinoma is associated with poor prognosisHuihui ZhangBE, Fan QiDE, Youhan CaoBC, Minfeng ChenFG, Xiongbing ZuAEG
Med Sci Monit 2014; 20:812-817
BACKGROUND: Down-regulation of microRNA-101 (miR-101) expression has been linked to bladder transitional cell carcinoma (BTCC) development. However, the relationship between the expression of miR-101 in BTCC and a patient’s prognosis has not yet been studied. Thus, we attempted to explore the correlation of miR-101 and clinicopathological factors of BTCC patients, and evaluate the impact of miR-101 on prognosis of BTCC.
MATERIAL AND METHODS: In 88 samples of BTCC (n=72) and normal tissues (n=16), the expressions of miR-101 were detected by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). The relationship of miR-101 and clinicopathological factors in BTCC was analyzed statistically. Survival analysis was performed to assess the prognostic significance of miR-101.
RESULTS: Down-regulation of miR-101 was found in BTCC tissues, compared with normal tissues (P<0.05). MiR-101 expression was significantly associated with tumor diameter, tumor stage, tumor grade, lymph node involvement, and lymph node metastasis (all P<0.05). Low-level expression of miR-101 was significantly correlated with shortened survival time (P<0.01). Multivariate Cox regression analysis revealed this significant prognostic impact was independent of other clinicopathologic factors (P<0.01).
CONCLUSIONS: Our results suggest that the expression of miR-101 is down-regulated in BTCC, which consequently favored tumor progression. MiR-101 may play an important role as a diagnostic and prognostic marker in BTCC.
Keywords: Urinary Bladder Neoplasms, Adult, Aged, 80 and over, Carcinoma, Transitional Cell - surgery, Down-Regulation - genetics, Kaplan-Meier Estimate, Multivariate Analysis, Prognosis, Urinary Bladder - pathology, Urinary Bladder Neoplasms - surgery
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