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Endovascular coil embolization of aneurysm neck for the treatment of ruptured intracranial aneurysm with bleb formation

Jun Wan, Weijin Gu, Xiaolong Zhang, Daoying Geng, Gang Lu, Lei Huang, Lei Zhang, Liang Ge, Lihua Ji

Department of Radiology, Jing’an District Centre Hospital of Shanghai Huashan Hospital Fudan University Jing’an Branch, Shanghai, China (mainland)

Med Sci Monit 2014; 20:1121-1128

DOI: 10.12659/MSM.890272

Available online:

Published: 2014-07-02

Background: Ruptured intracranial aneurysm (ICA) with bleb formation (RICABF) is a special type of ruptured ICA. However, the exact role and effectiveness of endovascular coil embolization (ECE) in RICABF is unknown.
We aimed to investigate the effectiveness and safety of ECE of aneurysm neck for RICABF treatment.
Material and Methods: We retrospectively assessed consecutive patients who were hospitalized in our endovascular intervention center between October 2004 and May 2012. Overall, 86 patients underwent ECE of aneurysm neck for 86 RICABF. Treatments outcomes included secondary rupture/bleeding rate, aneurysm neck embolization rate, residual/recurrent aneurysm, intraoperative incidents, and post-embolization complications, as well as improvements in the Glasgow outcome scale (extended) (GOS-E).
Results: Complete occlusion was achieved in 72 aneurysms (72/86, 83.7%), while 12 aneurysms (12/86, 14.0%) had a residual neck, and 2 aneurysms (2/86, 2.3%) had a residual aneurysm. The postoperative GOS-E was 3 in 3 patients (3.5%), 4 in 10 patients (11.6%), and 5 in 73 patients (84.9%). Follow-up angiography was performed in all patients (mean 9.0 months, interquartile range of 9.0). Recurrence was found in 3 patients (3/86, 3.5%). No aneurysm rupture or bleeding was reported.
Conclusions: Our mid-term follow-up study showed that ECE of aneurysm neck was an effective and safe treatment modality for RICABF. The long-term effectiveness and safety of this interventional radiology technique need to be investigated in prospective and comparative studies.

Keywords: Embolization, Therapeutic - adverse effects, Blister - radiography, Aneurysm, Ruptured - therapy, Adult, Endovascular Procedures - adverse effects, Follow-Up Studies, Intracranial Aneurysm - therapy, Postoperative Complications - etiology, Subarachnoid Hemorrhage - radiography, Tomography, X-Ray Computed