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22 April 2014 : Original article

Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards

Ewa BocianBCDEF, Wanda GrzybowskaBCDE, Stefan TyskiACDEG

DOI: 10.12659/MSM.890175

Med Sci Monit 2014; 20:666-673

Abstract

BACKGROUND: The history of the investigation of standardized mycobactericidal activity of disinfectants and antiseptics is not very long. There is growing interest among the manufacturers of disinfectants in carrying out research on the antimicrobial activities in accordance with European standards (EN). This research could facilitate the introduction of high-quality disinfectants to the market. The aim of this study was to evaluate the mycobactericidal activity of selected chemical disinfectants and antiseptics used in the medical and veterinary fields.

MATERIAL AND METHODS: This study included 19 products submitted to the National Medicines Institute in Poland for evaluation of mycobactericidal activity. These products contain in their composition active substances belonging to different chemical groups, including aldehydes, alcohols, amines, quaternary ammonium compounds, phenols, guanidine, and oxidizing compounds. This study, conducted according to the manufacturers’ description of the preparations, was carried out in accordance with European standards, which also met the Polish standards: PN-EN 14204: 2013, PN-EN 14348: 2006, and PN-EN 14563: 2012.

RESULTS: Tested products for disinfection and antiseptics containing active substances from different chemical groups showed high mycobactericidal activity and met the requirements of the appropriate European standards in most cases. In the case of products containing guanidine and amine compounds, the concentration of active ingredients used in the test and the test conditions specified by the manufacturer did not provide the mycobactericidal activity required by the standards.

CONCLUSIONS: Prior to the launch of a new product on the market, it is important to establish the appropriate usage and testing conditions of the preparation, such as its practical concentration, contact time, and environment condition (clean or dirty).

Keywords: Anti-Infective Agents, Local - standards, Anti-Bacterial Agents - standards, Disinfectants - standards, Europe, Microbial Sensitivity Tests, Mycobacterium - drug effects, Reference Standards

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750