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Medical Science Monitor Basic Research


eISSN: 1643-3750

Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction

Ahmet Temiz, Emine Gazi, Ömer Güngör, Ahmet Barutçu, Burak Altun, Adem Bekler, Emine Binnetoğlu, Hacer Şen, Fahri Güneş, Sabri Gazi

Department of Cardiology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

Med Sci Monit 2014; 20:660-665

DOI: 10.12659/MSM.890152

Available online: 2014-04-22

Published: 2014-04-22


Background: Platelet-to-lymphocyte ratio (PLR) is a new prognostic marker in coronary artery disease. We aimed to evaluate the relationship between PLR and in-hospital mortality in patients with ST-elevated acute myocardial infarction (AMI).
Material and Methods: The present study included 636 patients with ST-elevated AMI. The study population was divided into tertiles based on their admission PLR. Patients having values in the third tertile was defined as the high PLR group (n=212) and those having values in the lower 2 tertiles were defined as the low PLR group (n=424).
Results: Risk factors of coronary artery disease and treatments administered during the in-hospital period were similar between the groups. Male patient ratio was found to be lower in the high PLR group (73% vs. 82.8%, p=0.004). In-hospital mortality was increased in the high PLR group when compared to the low PLR group (12.7% vs. 5.9%, p=0.004). The PLR >144 was found to be an independent predictor of in-hospital cardiovascular mortality (HR: 2.16, 95% CI: 1.16–4.0, p=0.014).
Conclusions: This study showed that PLR is an independent predictor of cardiovascular mortality in patients with ST-elevated AMI.

Keywords: Blood Platelets - pathology, Electrocardiography, Hospital Mortality, Lymphocytes - pathology, Myocardial Infarction - physiopathology, ROC Curve, Risk Factors