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15 November 2013 : Original article

Elevated red cell distribution width and inflammation in printing workers

Ahmet CelikABCDEFG, Neriman AydinACD, Birgul OzcirpiciACDG, Edibe SaricicekDEF, Hatice SezenBCDG, Mehmet OkumusBCDG, Selim BozkurtBCDG, Metin KilincCEG

DOI: 10.12659/MSM.889694

Med Sci Monit 2013; 19:1001-1005

Abstract

BACKGROUND: The aim of this study was to estimate the effects of exposure to chemical compounds on systemic biochemical inflammatory markers in printing industry workers.

MATERIAL AND METHODS: Fifty-eight printing workers from 19 different small- and medium-sized enterprises in the printing sector were investigated. For comparison, 80 healthy workers not subjected to workplace chemicals served as control subjects.

RESULTS: No significant differences were observed between the printing workers and control subjects with respect to age, BMI, waist circumference/hip circumference ratio, smoking, and alcohol consumption. Printing workers had significantly higher serum TNF-alpha levels (11.02±5.34 vs. 9.26±3.87 pg/ml, p=0.039), plasma fibrinogen levels (1.74±0.49 vs. 1.38±0.5 mg/dl, p=0.012), and red blood cell distribution width (RDW-SD) (49.77±3.09 vs. 47.3±2.88 p<0.01) compared to control subjects.

CONCLUSIONS: Elevation of RDW, serum TNF-alpha, and plasma fibrinogen levels in printing workers may be due to systemic toxic effects of chemical compounds used in this sector. TNF-alpha is an inflammatory cytokine that has a wide spectrum of biological activities, and fibrinogen plays an important role in pathological processes. Some compounds may be carcinogenic or mutagenic. Better designed workplaces and working conditions will help to reduce the hazardous effects of chemical compounds.

Keywords: Erythrocytes - drug effects, Case-Control Studies, Blood Cell Count, Fibrinogen - analysis, Hazardous Substances - adverse effects, Immunoassay, Inflammation - chemically induced, Occupational Exposure - adverse effects, Printing, Statistics, Nonparametric, Tumor Necrosis Factor-alpha - blood, Turkey

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750