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eISSN: 1643-3750

MicroRNA-132 may play a role in coexistence of depression and cardiovascular disease: A hypothesis

Zhihua Zheng, Yingtong Zeng, Hongbing Huang, Feng Xu

Med Sci Monit 2013; 19:438-443

DOI: 10.12659/MSM.883935

Available online:

Published: 2013-06-07


Different individuals have different degrees of neuroplasticity due to their different experiences. Neuroplasticity may play a role in individual differences among neuropsychiatric disease treatment efficacy. Since the nervous system monitors and coordinates internal organ function, neuroplasticity may be associated with other diseases. Cardiovascular disease (CVD) is associated with depression, which is a disorder of disrupted neuroplasticity. MicroRNA-132 (miR-132) has a roles in neuroplasticity and cardiovascular function. Thus, we hypothesize that miR-132 may play a role in coexistence of depression and CVD.

Keywords: Models, Biological, MicroRNAs - metabolism, Depression - physiopathology, Cardiovascular System - pathology, Cardiovascular Diseases - genetics, Neuronal Plasticity - genetics



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