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Leptin and interferon-gamma as possible predictors of cesarean section among women with hypertensive disorders of pregnancy

Krzysztof Rytlewski, Hubert Huras, Katarzyna Kuśmierska-Urban, Aleksander Gałaś, Alfred Reroń

Med Sci Monit 2012; 18(8): CR506-511

DOI: 10.12659/MSM.883271

Available online: 2012-08-01

Published: 2012-08-01

Background:    This study was designed to evaluate maternal levels of leptin and interferon-gamma (IFN-gamma) in pregnancy complicated with hypertension and to assess the role of cytokines in predicting the risk of cesarean section.
    Material/Methods:    This was a cohort study with a prospective follow-up. After proportional sampling procedure, the study included the follow-up of 40 women with hypertensive disorders of pregnancy (pregnancy-induced hypertension [PIH] or preeclampsia [PE]) and 40 uncomplicated pregnancies. Women were followed from the time of admission to the delivery. Levels of leptin and interferon-gamma were measured in serum samples from all women. A p-value <0.05 was considered as significant.
    Results:    Significant increase in IFN-gamma and leptin concentration in women with pre-eclampsia was observed. We found a significant 1.4-fold increase in the risk of birth by cesarean section associated with the increase of the IFN-gamma concentration by 0.1 pg/ml and almost 3-fold increase in the risk associated with the increase of the leptin concentration.
    Conclusions:    IFN-γ and leptin might be risk markers of cesarean section in hypertension disorders of pregnancy, but further studies supporting this evidence are needed.

Keywords: Labor, Obstetric - blood, Interferon-gamma - blood, Hypertension, Pregnancy-Induced - blood, Cesarean Section, Case-Control Studies, Apgar Score, Adult, Leptin - blood, Linear Models, Pregnancy