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Medical Science Monitor Basic Research


eISSN: 1643-3750

Examination of chemosensory functions in patients with dysosmia

Ling Yang, Yongxiang Wei, Wei Zhang, Di Yu, Yuanyuan Ren, Kunyan Li, Yichen Guo, Jinfeng Zhang

Med Sci Monit 2012; 18(3): CR154-159

DOI: 10.12659/MSM.882520

Available online: 2012-02-20

Published: 2012-02-20

Background:    To examine changes of chemical sensory functions in patients with dysosmia.
    Material/Methods:    The 272 study subjects included 98 healthy volunteers, 86 subjects with hyposmia and 88 subjects with functional anosmia. Their chemical sensory functions were examined using olfactory event-related potentials (oERPs), trigeminal event-related potentials (tERPs), T&T olfactometer and triple drop method, respectively.
    Results:    The T&T results showed that the difference between patients and healthy subjects had statistical significance. The oERPs and tERPs results showed that patients with functional anosmia had N1 and P2 waves of prolonged latency and reduced amplitude when compared to healthy subjects with the difference of statistical significance. When compared to healthy subjects, patients with functional anosmia had clear hypogeusia and the difference had statistical significance. For the younger group there was significant difference between healthy subjects and patients in T&T, oERPs and tERPs results.
    Conclusions:    It is suggested by the apparently concomitant trigeminal nerve dysfunction and hypogeusia in patients with functional anosmia in this study that olfactory and nasal trigeminal function in young patients was clearly decreased. Our study suggests the possible application of oERPs, tERPs and three drops method in clinical diagnosis in Chinese populations and provides scientific evidence for treatment.

Keywords: Olfaction Disorders - physiopathology, Smell, Evoked Potentials, Case-Control Studies, Taste