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Medical Science Monitor Basic Research


eISSN: 1643-3750

Cardiotrophin-1 plasma levels are increased in patients with diastolic heart failure

Atac Celik, Semsettin Sahin, Fatih Koc, Metin Karayakali, Mehmet Sahin, Ismail Benli, Hasan Kadi, Turgay Burucu, Koksal Ceyhan, Unal Erkorkmaz

Med Sci Monit 2012; 18(1): CR25-31

DOI: 10.12659/MSM.882197

Available online:

Published: 2011-12-22


Background:    Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines and is increased in various cardiovascular diseases, including chronic heart failure. The aim of the study was to determine if plasma CT-1 is associated with diastolic heart failure (DHF) and to investigate the relationship between CT-1 and echocardiographic parameters.
    Material/Methods:    Fifty-seven consecutive patients (mean age 57±8 years, 24 males) diagnosed with DHF in our clinic and 33 controls (mean age 55±7 years, 12 males) were included in the study. All study participants underwent echocardiographic evaluation and blood samples were obtained.
    Results:    CT-1 and NT-proBNP values were significantly higher in DHF subjects than in controls (11.30 [8.09–16.51] vs. 17.5 [8.95–28.74] fmol/mL, P=0.017 and 64 [27.5–95] vs. 82 [55.5–241] pg/mL, P=0.009, respectively). The mitral peak velocity of early diastolic filling (E), mean ratio of E to early diastolic mitral annular velocity (E/Em), and the pulmonary capillary wedge pressure (PCWP) estimated from E/Em measurements were all significantly higher in the patient group (62.27±14.69 vs. 75.67±18.85 cm/sec, 6.40±1.48 vs. 10.30±3.48, and 10 [9–11] vs. 14[12–16] mmHg, P≤0.001 for all). Lateral and septal Em were significantly lower in the patient group (10.69±1.87 vs. 8.69±2.00 cm/sec and 8.91±1.22 vs. 6.65±1.58 cm/sec, P<0.001 for both). CT-1 positively correlated with NT-proBNP (P=0.001, r=0.349), mean E/Em (P=0.003, r=0.307), and estimated mean PCWP (P=0.001, r=0.308).
    Conclusions:    CT-1 is elevated in patients with DHF and is associated with NT-proBNP and estimated left ventricular filling pressures.

Keywords: Natriuretic Peptide, Brain - blood, Peptide Fragments - blood, Heart Failure, Diastolic - blood, Echocardiography, Cytokines - blood, Blood Flow Velocity, Statistics, Nonparametric