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01 December 2011

Non-invasive assessment of hemispheric language dominance by optical topography during a brief passive listening test: A pilot study

Stefano BembichABCDEF, Sergio DemariniADEF, Andrea ClariciADG, Stefano MassaccesiABCD, Domenico Loenardo GrassoADEF

DOI: 10.12659/MSM.882128

Med Sci Monit 2011; 17(12): CR692-697

Abstract

Background: The Wada test is usually used for pre-surgical assessment of language lateralization. Considering its invasiveness and risk of complications, alternative methods have been proposed but they are not always applicable to non-cooperative patients. In this study we explored the possibility of using optical topography (OT) – a multichannel near-infrared system – for non-invasive assessment of hemispheric language dominance during passive listening.
Material/Methods: Cortical activity was monitored in a sample of healthy, adult Italian native speakers, all right-handed. We assessed changes in oxy-haemoglobin concentration in temporal, parietal and posterior frontal lobes during a passive listening of bi-syllabic words and vowel-consonant-vowel syllables lasting less then 3 minutes. Activated channels were identified by t tests.
Results: Left hemisphere showed significant activity only during the passive listening of bi-syllabic words. Specifically, the superior temporal gyrus, the supramarginal gyrus and the posterior inferior parietal lobe were activated.
Conclusions: During passive listening of bi-syllabic words, right handed healthy adults showed a significant activation in areas already known to be involved in speech comprehension. Although more research is needed, OT proved to be a promising alternative to the Wada test for non-invasive assessment of hemispheric language lateralization, even if using a particularly brief trial, which has been designed for future applications with non-cooperative subjects.

Keywords: Language, Dominance, Cerebral - physiology, Diagnostic Techniques and Procedures, Cerebrum - physiology, Adult, Acoustic Stimulation, Oxyhemoglobins - metabolism, Pilot Projects, Spectroscopy, Near-Infrared - methods

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750