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Proanthocyanidin prevents myocardial ischemic injury in adult rats

Adem Guler, Mehmet Ali Sahin, Orhan Yucel, Mehmet Yokusoglu, Mehmet Gamsizkan, Ertugrul Ozal, Ufuk Demirkilic, Mehmet Arslan

Med Sci Monit 2011; 17(11): BR326-331

DOI: 10.12659/MSM.882042

Published: 2011-10-26

Background:    Proanthocyanidin is a bioflavonoid known to have protective effect against oxidative injury. We investigated the cardioprotective effect of proanthocyanidin.
    Material/Methods:    Thirty-two Rattus Norvegicus rats were categorized equally as the control group (CG), proanthocyanidin group (PCG), ischemia group (IG) and proanthocyanidin-treated group (PCT). Rats in CG and IG were fed standard rat food and PCG and PCT were fed standard rat food plus proanthocyanidin (100 mg/kg/day twice a day by oral gavage) for 3 weeks. In CG and PCG the myocardial samples were prepared immediately, and in IG and PCT hearts were placed in transport solution and kept at 4°C for 5 hours, then prepared for evaluation. Malondialdehyde (MDA) level, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were measured.
    Results:    MDA levels were significantly higher in IG and PCT than in CG and PCG. The activity of SOD was significantly lower in IG and higher in PCG than in the other groups. The activity of GPx was significantly lower in IG than in the other groups. The activities of CAT were significantly lower in IG and PCT than in the other groups and were significantly lower in IG than PCT. Histopathologic evaluation revealed normal findings in CG and PCG. While ischemic injury was observed in IG, the content of muscle fibers was better preserved in PCT.
    Conclusions:    Proanthocyanidin may have a protective effect on myocardial ischemic injury.

Keywords: Proanthocyanidins - pharmacology, Oxidative Stress - physiology, Myocardial Reperfusion Injury - prevention & control, Malondialdehyde - metabolism, Heart Ventricles - pathology, Grape Seed Extract - pharmacology, Glutathione Peroxidase - metabolism, Catalase - metabolism, Animals, Rats, Statistics, Nonparametric, Superoxide Dismutase - metabolism