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21 June 2011

Association between Takayasu arteritis and ulcerative colitis – case report and review of serological HLA analysis

Nobuyuki TakahashiABDEF, Kazuaki TanabeDEF, Takashi SugamoriB, Masatake SatoB, Jun KitamuraB, Hidetoshi SatoB, Hiroyuki YoshitomiB, Yutaka IshibashiD, Toshio ShimadaD

DOI: 10.12659/MSM.881837

Med Sci Monit 2011; 17(7): CS81-84

Abstract

Background: Takayasu arteritis and ulcerative colitis are immune-mediated inflammatory diseases; genetic factors are assumed to play an important role in the pathogenesis of these 2 diseases. However, the coexistence of these 2 diseases has rarely been reported.
Case Report: In this report, we present a rare case of a 29-year-old man with a 4 years history of ulcerative colitis who developed Takayasu arteritis. He was found to carry the following human leukocyte antigens (HLA): A11, A24, B52, B62, DR4, and DR9.
Conclusions: We present a case report and review of the pertinent literature on serological analysis of HLA haplotype of the patients who exhibit both these diseases. In patients with both Takayasu arteritis and ulcerative colitis, high frequency of HLA-A24, B52, and DR 2 is observed. The pathological relevance of HLA-A24, B52, and DR2 to concomitant Takayasu arteritis and ulcerative colitis requires further investigation.

Keywords: Serologic Tests - methods, Magnetic Resonance Angiography, Japan, Haplotypes - genetics, HLA-DR2 Antigen - blood, HLA-B52 Antigen, HLA-B Antigens - blood, HLA-A24 Antigen, HLA-A Antigens - blood, Genome-Wide Association Study, Electrocardiography, Echocardiography, Colitis, Ulcerative - pathology, Takayasu Arteritis - pathology, Tomography, X-Ray Computed

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750