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Medical Science Monitor Basic Research


eISSN: 1643-3750

Influence of pretreatment with H2 receptor antagonists on the cure rates of Helicobacter pylori eradication

Chikako Tokoro, Masahiko Inamori, Tomoko Koide, Yusuke Sekino, Hiroshi Iida, Yasunari Sakamoto, Hiroki Endo, Kunihiro Hosono, Hirokazu Takahashi, Masato Yoneda, Hiroaki Yasuzaki, Masami Ogawa, Yasunobu Abe, Kensuke Kubota, Satoru Saito, Ichiro Kawana, Atsushi Nakajima, Shin Maeda, Reikei Matsuda, Daisuke Takahashi

Med Sci Monit 2011; 17(5): CR235-240

DOI: 10.12659/MSM.881762

Available online: 2011-04-24

Published: 2011-04-24

Background:    Pretreatment with a proton pump inhibitor (PPI) reportedly decreases the efficacy of Helicobacter pylori (H. pylori) eradication, however, the effect of pretreatment with an H2 receptor antagonist (H2RA) on H. pylori eradication has not yet been studied. We compared the efficacy of eradication regimen (lansoprazole/amoxicillin/clarithromycin) in patients with H. pylori infection with or without H2RA pretreatment.
    Material/Methods:    In this retrospective study conducted at three centers, 310 patients with H. pylori infection were treated. The diagnosis of H. pylori infection was made using the rapid urease test, bacterial cultures and histological examination of endoscopic biopsy specimens. The patients were assigned to receive an eradication regimen first or following pretreatment with H2RA. Eradication was assessed using the 13C-urea breath test more than 4 weeks after the completion of therapy.
    Results:    Overall, H. pylori was eradicated in 79.7% of the cases: the eradication rate was 81.6% in the pretreatment group, and 77.6% in the eradication first group (p=0.3799, chi-square test). No significant difference in the eradication rate was observed between the two groups.
    Conclusions:    Pretreatment with H2RA had no significant influence on the efficacy of H. pylori eradication therapy.

Keywords: Logistic Models, Histamine H2 Antagonists - pharmacology, Helicobacter pylori - drug effects, Aged, 80 and over, Adult, Treatment Failure, young adult