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01 December 2008

Recurrent pericarditis as the initial manifestation of Familial Mediterranean fever

Kerem OkuturABDEF, Selcuk SeberBDEF, Erkan OztekinBF, Cemal BesBF, Fatih BorluBF

Med Sci Monit 2008; 14(12): CS139-141 :: ID: 869467

Abstract

Background
Familial Mediterranean fever is an autosomal recessive disease largely restricted to certain ethnic groups and presenting with recurrent febrile serositis attacks. Peritonitis, pleuritis, and synovitis are common manifestations; however, the pericardium is rarely affected.
Material and Method
In this case report, we describe a 25-year-old Turkish woman who presented with recurrent pericarditis of no obvious cause, which eventually responded to colchicine therapy. Using gene mutation analysis to detect the MEFV gene, the patient's condition was finally diagnosed as Familial Mediterranean fever.
Results

Conclusions
Familial Mediterranean fever should be considered in patients with idiopathic recurrent pericarditis unresponsive to nonsteroidal anti-inflammatory medications and corticosteroids. Mutation analyses should be done.

Keywords: Pericarditis - physiopathology, Recurrence, Familial Mediterranean Fever - physiopathology, Echocardiography, Cytoskeletal Proteins - genetics, Adult

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Medical Science Monitor eISSN: 1643-3750
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