02 October 2008
Med Sci Monit 2008; 14(10): BR189-192 :: ID: 869404
High intake of cruciferous vegetables has been associated with lower risk of various cancers, and the cancer preventive effect of the vegetables has been associated with their high levels of glucosinolates. The hydrolysis of glucosinolates results in the generation of bioactive compounds, including allyl nitrile which we previously found to be an active inducer of some phase 2 enzymes. In this study, we further explored the inductive ability of this nitrile in light of increasing evidence that antioxidants delay or prevent the development of cancer.
Material and Method
Groups of 6 mice were administered subtoxic doses of allyl nitrile (5, 50, 100 or 200 micromol/kg) or vehicle-distilled water daily for 5 days by gastric intubation. On the sixth day, the animals were sacrificed for examination of enzyme activities in their tissues. Enzymes tested were thioredoxin reductase (TR), glutathione peroxidase (GPx), glutathione reductase (GR) and catalase.
Allyl nitrile increased the activity of TR in the liver, kidneys and rectum at doses of 100-200 micromol/kg/day, and GPx in the kidneys and small intestine at 50 to 200 micromol/kg/day, while in the colon, alone, it decreased the activities of GR and catalase at doses of 200 and 100-200 micromol/kg/day, respectively not.
The present results suggest an involvement of allyl nitrile in antioxidant defense in the body, except for the colon.
Keywords: Thioredoxin-Disulfide Reductase - metabolism, Nitriles - pharmacology, Glutathione Reductase - metabolism, Metabolic Detoxication, Drug, Glutathione Peroxidase - metabolism, Glucosinolates - metabolism, Catalase - metabolism, Tissue Distribution, Brassicaceae - chemistry, Antioxidants - metabolism
01 May 2022 : EditorialEditorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19
Med Sci Monit 2022; 28:e937048
04 May 2022 : Clinical ResearchEffects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...
Med Sci Monit In Press; DOI: 10.12659/MSM.936069
22 April 2022 : Clinical ResearchFactors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)
Med Sci Monit In Press; DOI: 10.12659/MSM.936547
24 May 2022 : Clinical ResearchRemimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing ...
Med Sci Monit In Press; DOI: 10.12659/MSM.936580
23 May 2022 : Clinical ResearchFully Automatic Knee Joint Segmentation and Quantitative Analysis for Osteoarthritis from Magnetic Resonanc...
Med Sci Monit In Press; DOI: 10.12659/MSM.936733
Most Viewed Current Articles
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996