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29 August 2008

p53 codon 72 polymorphism and HPV status in lung cancer

Nur BuyruADEFG, Julide AltinisikBC, Mustafa IsinBC, Nejat DalayAEF

Med Sci Monit 2008; 14(9): CR493-497 :: ID: 867968

Abstract

Background
Several risk factors, both environmental and genetic, have been associated with the pathogenesis of lung cancer. A common polymorphism at codon 72 of exon 4 of the p53 gene encoding either an arginine or proline has been shown to confer susceptibility to the development of different human malignancies. This polymorphism affects proteolytic degradation of p53 promoted by the HPV-E6 protein and represents a risk factor for human-papillomavirus-induced carcinogenesis.
Material and Method
A total of 65 patients with lung cancer were recruited into the study and 87 healthy subjects were used as the control group. The codon 72 polymorphism was determined by the PCR-RFLP method. Presence of human papillomavirus DNA was analyzed by polymerase chain reaction using MY09 and MY11 consensus primers and hybridization with HPV16 and HPV18 specific probes.
Results
The frequencies of the Arg and Pro alleles were 68.46% and 31.54% in lung cancer patients and 55.7% and 44.3% in the healthy control subjects, respectively. These differences were statistically significant. Human papillomavirus DNA was detected in the blood circulation of only 1 patient.
Conclusions
Our results suggest that the Arg/Arg genotype may represent a potential risk factor for the development of lung cancer independent of the HPV infection.

Keywords: Polymorphism, Genetic, Repressor Proteins - genetics, Papillomavirus Infections - pathology, Oncogene Proteins, Viral - genetics, Lung Neoplasms - virology, Genotype, Genetic Predisposition to Disease, Gene Frequency, Tumor Suppressor Protein p53 - genetics, DNA-Binding Proteins - genetics, DNA, Viral - blood, Codon - genetics, Aged, 80 and over

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750