Logo MSM

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo MSM Logo MSM Logo MSM

01 July 2008

Interaction of clinical suspicion and PET in the diagnosis of suspected thoracic malignancy

Daniel BaramABCDEF, Thomas V BilfingerABCDEF

Med Sci Monit 2008; 14(7): CR379-383 :: ID: 863668

Abstract

Background
This study assesses the accuracy and interaction of clinical suspicion and positron emission tomography (PET) scans in diagnosis of suspected thoracic malignancy.
Material and Method
313 patients evaluated in a University Hospital lung cancer evaluation center who underwent PET scanning and subsequently had tissue confirmation or a course of stability by CT scans over a period of two years. At the time of the initial visit, clinical suspicion based on history, physical exam and computerized tomography (CT) characteristics was assigned as low, intermediate or high probability of malignancy. Subsequently PET results were classified as negative, intermediate or positive, based on standardized uptake value [SUV] of 0, between 0 and 2.5, greater than 2.5 respectively.
Results
ROC analysis showed similar results for clinical suspicion (0.762) and PET (0.779). High clinical suspicion and positive PET had a PPV of 96.6%; low clinical suspicion and negative PET had a NPV of 100%. When PET and clinical suspicion were fully discordant, clinical suspicion was accurate in 80%, PET in 20%. When PET scan or clinical suspicion was intermediate, 35% were malignant.
Conclusions
Clinical suspicion and PET are both accurate in diagnosing thoracic malignancy. When suspicion and PET are concordant, diagnostic accuracy is very high; when discordant, clinical suspicion was more accurate. When clinical suspicion or PET were intermediate, there is a significant likelihood for cancer.

Keywords: Risk Factors, Physician's Role, Positron-Emission Tomography, Lung Neoplasms - radionuclide imaging

0 Comments

This Week Editorial

20 September 2021 : Editorial

Editorial: Autoantibodies to Components of the Immune System, Including Type 1 Interferons, and the Risk of Severe COVID-19

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.934766

Med Sci Monit 2021; 27:e934766

Coronavirus/Covid 19

22 September 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

08 September 2021 : Clinical Research

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

Med Sci Monit In Press; DOI: 10.12659/MSM.932788  

16 July 2021 : Review article

Silent Hypoxemia in Patients with COVID-19 Pneumonia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.930776  

09 July 2021 : Database Analysis

A Simple Clinical Prediction Tool for COVID-19 in Primary Care with Epidemiology: Temperature-Leukocytes-CT...

Med Sci Monit In Press; DOI: 10.12659/MSM.931467  

In Press

23 Sep 2021 : Animal Research

Forkhead Box Protein M1 Promotes Nasopharyngeal Carcinoma Cell Tumorigenesis Possibly via the Wnt/β-Catenin...

Med Sci Monit In Press; DOI: 10.12659/MSM.931970  

22 Sep 2021 : Editorial

Editorial: Global Regulatory Initiatives Deliver Accelerated Approval of the First Bispecific Therapeutic M...

Med Sci Monit In Press; DOI: 10.12659/MSM.934854  

22 Sep 2021 : Clinical Research

A Comparative Study of the Clinical Efficacy and Safety of Pneumatic Trabeculoplasty and Selective Laser Tr...

Med Sci Monit In Press; DOI: 10.12659/MSM.933454  

20 Sep 2021 : Clinical Research

Comparison of the Use of Magnetic Resonance Imaging of Partial Anterior Cruciate Ligament Tears Using Maxim...

Med Sci Monit In Press; DOI: 10.12659/MSM.932228  

Most Viewed

20 Mar 2020 : Clinical Research

Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...

DOI :10.12659/MSM.923921

Med Sci Monit 2020; 26:e923921

15 Apr 2020 : Clinical Research

Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...

DOI :10.12659/MSM.924171

Med Sci Monit 2020; 26:e924171

05 May 2020 : Review article

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

DOI :10.12659/MSM.924700

Med Sci Monit 2020; 26:e924700

26 Apr 2020 : Clinical Research

Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...

DOI :10.12659/MSM.924609

Med Sci Monit 2020; 26:e924609

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750