Med Sci Monit 2000; 6(4): MT791-795 :: ID: 508232
Background: The rate of ocular growth can be modified by the imposition of either plus or minus lenses before the eyes, which creates changes in retinal defocus. Several hypotheses with relatively complicated mechanisms have been proposed to explain these changes, but the underlying mechanism has remained elusive.
Material/Methods: Our new analysis using schematic models, however, provides a relatively simple and logically-consistent explanation of how retinal defocus magnitude alone during ocular growth gives the requisite sign for an appropriate change in ocular growth rate.
Results: During a normal genetically-determined incremental increase in axial length, the presence of either an imposed plus or minus lens results in an increase or decrease, respectively, of the blur circle magnitude. Neuromodulators in the retina are proposed to regulate the sensitivity to retinal-image contrast by means of a local feedback mechanism, and the alteration in retinal-image contrast associated with the change in blur circle causes an increase or decrease, respectively, in the rate of release of neuromodulators as well as the rate of proteoglycan synthesis, the latter being associated with the structural integrity of the sclera.
Conclusions: This provides the critical sign, as well as amplitude, information needed to modulate appropriately the rate of eye growth, to result in a decrease or increase, respectively, in the rate of ocular growth.
Keywords: contrast, Myopia, axial length growth rate, retinal-defocus, refractive error development
01 December 2021 : EditorialEditorial: Cardiovascular Complications at One Year After SARS-CoV-2 Infection are Independent of Underlying Cardiovascular Risk Factors or Severity of COVID-19
Med Sci Monit 2022; 28:e937048
04 May 2022 : Clinical ResearchEffects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...
Med Sci Monit In Press; DOI: 10.12659/MSM.936069
22 April 2022 : Clinical ResearchFactors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)
Med Sci Monit In Press; DOI: 10.12659/MSM.936547
27 April 2022 : Meta-AnalysisEffect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review...
Med Sci Monit In Press; DOI: 10.12659/MSM.935823
20 May 2022 : Clinical ResearchEfficacy of Focused Extracorporeal Shock Wave Therapy in Chronic Low Back Pain: A Prospective Randomized 3-...
Med Sci Monit In Press; DOI: 10.12659/MSM.936614
19 May 2022 : Clinical ResearchAssociation Between Serum Homocysteine Levels and Severity of Diabetic Kidney Disease in 489 Patients with ...
Med Sci Monit In Press; DOI: 10.12659/MSM.936323
18 May 2022 : Clinical ResearchPhysical and Psychosocial Concept Domains Related to Health-Related Quality of Life (HRQL) in 50 Girls and ...
Med Sci Monit In Press; DOI: 10.12659/MSM.936801
Most Viewed Current Articles
31 Dec 1969 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
31 Dec 1969 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
31 Dec 1969 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996