Combination of diet, exercise and intermittent treatment of cimetidine on body weight and maintenance of weight loss. A 42 months follow-up study
Grethe Stoa Birketvedt, Erling Thom, Bjorn Bernersen, Jon FlorholmenMed Sci Monit 2000; 6(4): CR699-703 :: ID: 508165
Abstract
Introduction: The aim of the study was to investigate the long term effect of diet, exercise and intermittent treatment of cimetidine on body weight and maintenance of weight lost during treatment.
Material and methods: Fifty women and five men who had completed a 8 week randomized double-blind, placebo-controlled trial of cimetidine for weight loss were invited to participate in an open, non-randomized follow-up study of 42 months. The study was designed to compare weight loss and/or weight gain in subjects who, dependent on their level of motivation, volunteered to participate in an intervention or non-intervention group. In the intervention group the subjects were treated with cimetidine for 8 weeks twice a year, followed a diet restriction and performed regular exercise. In the non-intervention group the subjects had no behavioral treatment. Twenty two subjects volunteered to participate in the intervention program whereas 33 subjects volunteered to participate in the non-intervention group.
Results: In the intervention group, non-significant reductions in body weight (1.9±5.5 kg), BMI (0.6±1.7 kg/m2), body fat% (1.7±2.9) and waist circumference (2.1±5.9 cm) were found. In the non-intervention group there was a significant increase in body weight (7.5±5.3 kg), BMI (2.6±1.8 kg/m2), body fat% (3.0±3.3) and waist circumference (6.7±5.1 cm). Among the group of subjects initially treated with cimetidine for 8 weeks and who followed a subsequent intervention of additional 42 months (n=16), there was a 15.1% weight loss. Among the group initially treated with placebo for 8 weeks and who volunteered to participate in the non-intervention group (n=22), there was a weight gain of 8.6%. In conclusion, the combination of diet restriction, regular exercise and intermittent treatment of cimetidine appears to have long term effects on body weight and maintenance of weight loss.
Keywords: cimetidine, weight maintenance, body fat, Body Weight
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952